Synonyms in Detail: proband and propositus Usage & Differences

What context can I use each word in?

Learn when and how to use these words with these examples!

proband

Example

The proband's DNA was analyzed to determine the presence of the genetic mutation. [proband: noun]

Example

The proband was asked to complete a questionnaire about their medical history. [proband: noun]

Example

During the genetic counseling session, the proband's family history was discussed. [proband: adjective]

propositus

Example

The propositus was the first person in the family to show symptoms of the disease. [propositus: noun]

Example

The propositus's family tree was used to trace the inheritance of the genetic trait. [propositus: noun]

Example

The propositus was selected for the study due to their unique medical history. [propositus: adjective]

Good things to know

Which word is more common?

Proband is more commonly used than propositus in everyday language, especially in medical and scientific fields. Propositus is a less common term that is mainly used in genealogy and family history research.

What’s the difference in the tone of formality between proband and propositus?

Both proband and propositus are formal terms that are mainly used in specialized fields. However, proband has a more clinical and technical connotation, making it slightly more formal than propositus which has a more historical and genealogical connotation.

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