Can I say "cleanse you" instead of "clean you up"?
Yes, you can say "cleanse you" here instead of "clean you up". However, the verb "cleanse" sounds much more formal than the verb "clean", and in the context of the video it may sound weird to make the sentence more formal. Regardless of the formality, "cleanse" expresses the same meaning as "clean", and so it would be fine to replace it here.
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