student asking question

I suppose "oh, brother" has the same meaning as sighing. Then, can I say "oh, sister" as well?

teacher

Native speaker’s answer

Rebecca

"Oh, brother" is an informal exclamation used to express disappointment or frustration. "Oh, sister" is not used at all, but expressions like "oh, boy" and "oh, man" are! Ex: Oh, brother. Here we go again. Ex: Oh, boy. I accidentally messed it up again.

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