The expression "what's up" is definitely a familiar term. However, does it considered slang? Would it be inappropriate to say it in important circumstances?

Native speaker’s answer
Rebecca
"What's up" is considered slang because it's only used in informal situations and is not considered to be formal English. You shouldn't use this in formal or professional settings. You can use this with your friends or siblings as a greeting, but it would not be appropriate to say during a job interview or business meeting, for example. Ex: What's up, Mary? Did you do your homework? = peer, so you can use the expression Ex: Hello, Mr. Smith. I completed my homework. = teacher, so it's inappropriate to use this expression (unless your teacher specifically says it's ok)