Is he saying "some of you guys" because generalizing sounds rude?

Native speaker’s answer
Rebecca
Actually, he uses it in a slightly sarcastic way here. It is obvious that Muslims and Hindus are different, but many Americans are ignorant of this fact. Thus, he is pointing out this ignorance in the video. Whenever you see or hear the phrases "some of you don't know" or "for those of you who don't know," it is often meant in a sarcastic or condescending way because the speaker believes the topic or point to be common knowledge. You can figure out the implied meaning based on context and tone of voice! Ex: For those of you that don't know, people who wear turbans are not Muslim. Ex: Some of you might not know, so I'll explain.