why is 'with' used here instead of 'in'?

Rebecca

"With" is used here since they mean the purpose or use of one's life and the actions one takes with it, rather than "in," which would indicate the duration and time within one's life and how one spends their time. Ex: What you do with your life is your choice. Ex: What you do in your life is your choice. Ex: What are you going to do with all these old books? Ex: Let's see how many arcade games we can plan in 10 minutes.